I built a virtual machine using paravirtual drivers, both for network and for drive controllers, and used the most recent TurnKey ISO build to get MineOS going (first time user)
I successfully installed everything, had my server going and was able to reach the web UI for all 3 systems (console, webmin, mineOS)
Within seconds to minutes of authenticating, I noticed several messages that my submissions (i.e. creating a new profile, attempting to manage my network settings from webmin) were not accepted, timing out, etc.
I thought maybe it was a network issue on my end since I had made a change in my ARP table and adjusted my DHCP server to assign a specific IP to the newly built VM.
I rebuilt the virtual machine using the same virtual hardware and keeping the same MAC address and ended up with the same problems. I noticed ping loss and general connectivity issues.
I had no other issues with my 3 other virtual machines (i run plex and other backend debian boxes) and had a hunch after trying to install the vmware tools (and tried on the second shot with open-vm-tools); I rebuilt the virtual machine, but this time I changed my network card from the VMXNET3 to e1000 and, so far, everything works as expected.
One thing to note is that I am using ESXi 6 so it is a fairly recent set of drivers and therefore may not be configured correctly for the TurnKey kernel.
I wrote Will on youtube and he suggested I post on here, so there we are.